This is a premixed vial of BPC-157 and TB-500, usually 5 mg of each (10 mg total), nicknamed the Wolverine stack after the comic-book hero who heals fast. BPC-157 is a lab-made piece of a protein found in stomach juice, and TB-500 is a lab-made version (or short piece) of thymosin beta-4, a protein your body uses to repair tissue. Neither is an approved medicine.
How it works
In animal studies, BPC-157 seems to help new blood vessels grow and helps tendon cells grow and move, while thymosin beta-4 helps cells move into a wound, helps blood vessels grow and calms swelling. The idea is that one works more on blood supply and the other more on moving repair cells in, so together they might cover more ground. That's a theory, not something proven in people.
What people use it for
Tendon and ligament injuries
Pulled muscles
Injuries that heal slowly
Joint pain after training
The evidence
Mostly animal studies
Each part has animal and lab studies, but there are no good human trials of either one for injuries, and none of the blend. One 2026 rat study tested both on cut Achilles tendons: each helped alone, but the combo did no better than either one, so the idea that they add up isn't supported yet. Everything people say about this blend comes from personal experience, not trials.
Any time. Some split it into a morning and a night shot.
Cycle
4–6 weeks, then a break of similar length
Route
Subcutaneous injection, often near the injured area
Why: You dose by the BPC-157 part, since its usual daily range is the best known. In a 1:1 vial, a daily BPC-157 dose also gives you about 1.75–3.5 mg of TB-500 a week. That's close to what people use when taking TB-500 alone. Example: add 2 mL of bacteriostatic water to a 10 mg vial. That makes 5 mg/mL of blend (2.5 mg/mL of each). A 500 µg dose is 0.1 mL, or 10 units on a U-100 insulin syringe, and gives 250 µg of each peptide.
Low/starter
Reported
Dose
250 µg of blend (125 µg BPC-157 + 125 µg TB-500)
How often
Once a day
When
Any time
Cycle
First 1–2 weeks, then move to the standard dose if you feel fine
Route
Subcutaneous injection
Why: Starting low lets you see how your body reacts before you take more. With the 2 mL mix above, this is 0.05 mL, or 5 units.
Start at the low end, and change one thing at a time. If you take medication or have a health condition, check with a doctor first.
Is the blend better than taking each one separately?
Not proven. The only study of the pair (in rats) found no extra benefit from combining them. The upside is fewer shots. The downside is you can't change one dose without changing the other.
How do I work out my dose?
Pick your BPC-157 dose first, then double it to get the total blend dose for a 1:1 vial. The TB-500 dose comes along with it.
What if I only want more TB-500?
You can't with this vial. Raising the dose raises both. If you want different amounts, use two separate vials.
Sources
Biçer O, et al. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study. Jt Dis Relat Surg. 2026;37(3):822-837. PubMed 42542926
Staresinic M, et al. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J Orthop Res. 2003;21(6):976-83. PubMed 14554208
Malinda KM, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999;113(3):364-8. PubMed 10469335
Goldstein AL, et al. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51. PubMed 22074294
Mendias CL, et al. Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance. Sports Med. 2026;56(8):1921-1935. PubMed 41966639