Also called Delta sleep-inducing peptide, Emideltide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
A peptide first found in rabbits, hoped to deepen sleep, with mixed results in people.
DSIP is a chain of nine amino acids that Swiss researchers found in 1977 in the blood of rabbits whose brains were stimulated to sleep, and it's named after the deep 'delta' stage of sleep. Nobody has clearly found a matching human gene, so scientists still argue about what it does in the body. It isn't approved as a medicine anywhere.
It's not well understood. Animal studies suggest it affects sleep patterns, stress hormones and your body clock, but it doesn't work like a sleeping pill with one clear target. It also breaks down quickly in the blood.
Some human studies
Small 1980s studies by the Swiss team behind DSIP reported better sleep in people with chronic insomnia after IV shots, but those studies weren't blinded. When other groups ran placebo-controlled trials the effect was weak, and a Dutch study of 16 insomniacs found only small changes that may have been chance. There's no good modern research, and those studies didn't test the under-the-skin shots people use today.
Why: This is the dose from double-blind insomnia trials (Monti 1987, Bes 1992). Those trials found little real benefit over placebo.
Why: A widely shared range that hasn't been tested in trials. People take it near bedtime because the blood clears it within minutes.
Start at the low end, and change one thing at a time. If you take medication or have a health condition, check with a doctor first.
Set up for a 2 mg vial. Change any number to match yours. New to this? Read how to mix a vial and mg vs mL vs units first.
Pick your dose and how long you'll run it. We'll count what you need.
Get help right away for swelling of the face or throat, trouble breathing, chest pain, or a spreading, hot, red injection site.
Powder: fridge or freezer. Once mixed: fridge, use within about 2–3 weeks.
FDA: Not approved. Emideltide (DSIP) was placed on FDA's compounding safety-concern list in 2023, then removed in April 2026 after the nomination was withdrawn. In July 2026 an FDA advisory committee voted 6 in favor and 7 against allowing it in compounding.
Sport (WADA): Not approved by any health authority, so it falls under WADA's S0 (non-approved substances): prohibited at all times.
Unlikely. The best controlled trials found little or no difference from placebo.
It was first found in rabbits, but its role in humans is unclear. What's sold is made in a lab.
Better sleep habits, treating snoring or apnea, and CBT for insomnia (a type of talk therapy) have far more evidence. See a doctor if poor sleep lasts more than a few weeks.
Last checked 2026-10