KLOW is a premixed vial of four peptides: GHK-Cu, BPC-157, TB-500 and KPV. The usual mix is 50 mg GHK-Cu plus 10 mg each of the other three, 80 mg total (a 5:1:1:1 ratio), but some vials differ, so always check the label. It's the Wolverine blend (BPC-157 + TB-500) plus two more peptides, and none of the four is an approved medicine.
How it works
Each part targets a different piece of healing. In lab and animal studies, GHK-Cu (a copper-carrying peptide found in blood) turned on genes tied to collagen and skin repair, BPC-157 and TB-500's parent protein, thymosin beta-4, helped blood vessels grow and cells move into wounds, and KPV calmed gut inflammation in mice. The idea is repair plus less inflammation in one shot, but that's a theory pieced together from separate studies.
What people use it for
Injury recovery
Skin and wound healing
Gut inflammation
General recovery from training
The evidence
Mostly animal studies
No study has tested KLOW. Each part has lab or animal studies, and GHK-Cu has been used in skin creams, but there are no good human trials of any of the four as shots for healing. The only study that combined two of them (BPC-157 and TB-500, in rats) found no extra benefit, so the case for a four-way mix is theory, not proof.
1.6–2.4 mg of blend (about 1–1.5 mg GHK-Cu + 200–300 µg each of BPC-157, TB-500 and KPV)
How often
Once a day
When
Any time. Some prefer evening.
Cycle
4–6 weeks, then a break of similar length
Route
Subcutaneous injection
Why: Dose by BPC-157, the part with the best-known daily range. In a 5:1:1:1 vial, every 1 µg of BPC-157 also brings 5 µg of GHK-Cu. So GHK-Cu is what limits how high you can go. Example: add 4 mL of bacteriostatic water to an 80 mg vial. That makes 20 mg/mL of blend (2.5 mg/mL each of BPC-157, TB-500 and KPV, and 12.5 mg/mL of GHK-Cu). A dose with 250 µg of BPC-157 is 0.1 mL, or 10 units on a U-100 insulin syringe. That's 2 mg of blend total.
Low/starter
Reported
Dose
0.8 mg of blend (about 500 µg GHK-Cu + 100 µg each of the others)
How often
Once a day
When
Any time
Cycle
First 1–2 weeks
Route
Subcutaneous injection
Why: GHK-Cu often stings and can darken the skin where you inject. Starting low shows how you handle it. With the 4 mL mix above, this is 0.04 mL, or 4 units.
Start at the low end, and change one thing at a time. If you take medication or have a health condition, check with a doctor first.
We may earn a commission from these links. Counts include one syringe and two swabs per dose.
Stay safe
Side effects
Stinging or burning where you inject (common, from GHK-Cu)
Redness, lumps or bluish-gray skin darkening at the spot
Tiredness
Headache
Nausea
Side effects of all four can add up, and you can't tell which one caused a problem
Skip it if
Any cancer now or in the past (BPC-157 and TB-500 help new blood vessels grow)
Wilson's disease or any problem with your body storing copper (GHK-Cu adds copper)
Copper allergy
Pregnant or breastfeeding
Under 18
Competing in drug-tested sports
Interactions
No drug interactions have been studied
Copper supplements: GHK-Cu adds a little extra copper
Get help right away for swelling of the face or throat, trouble breathing, chest pain, or a spreading, hot, red injection site.
Storage & legal
Storage
Powder: fridge or freezer, out of the light. Mixed: fridge, use within about 4 weeks. A blue tint is normal (it's the copper).
Legal status
FDA: Not approved, alone or as a blend. FDA has listed BPC-157 among bulk substances with safety concerns for compounding (2023).
Sport (WADA): Prohibited. BPC-157 is named under S0 and thymosin beta-4 falls under S2.
Common questions
Is the 50/10/10/10 ratio standard?
It's the most common, but not fixed. Some vials use different amounts, so always do your math from your own vial's label.
Why is there so much GHK-Cu?
GHK-Cu is usually taken at higher doses than the other three, so the bigger share lets one shot hit a typical amount of each. It also means GHK-Cu side effects, like stinging, set your limit.
Can I take more BPC-157 without more GHK-Cu?
Not with this vial. All four parts move together. If you need different amounts, use separate vials.
Sources
Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. PubMed 29986520
Staresinic M, et al. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J Orthop Res. 2003;21(6):976-83. PubMed 14554208
Malinda KM, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999;113(3):364-8. PubMed 10469335
Biçer O, et al. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study. Jt Dis Relat Surg. 2026;37(3):822-837. PubMed 42542926