Typical dose2 drops of 0.15% solution in each nostril (roughly 100–300 µg per dose, depending on drop size)
How often3 times a day
Half-lifeMinutes in the blood; effects reported to last hours (animal data)
Vial sizes5 mg, 10 mg
The simple version
What it does
It's meant to ease anxiety without making you sleepy.
How people take it
The Russian leaflet says 2 drops in each nostril (roughly 100–300 µg), 3 times a day.
Know this
The only human studies are small ones from Russia that no outside team has repeated.
What it is
Selank is a lab-made peptide, a short chain of seven protein building blocks, first made in Russia from a small piece of an immune protein. In Russia it's a registered medicine sold as 0.15% nasal drops for anxiety and nervous exhaustion. It isn't approved in the US, EU or UK.
How it works
No one knows exactly. Russian lab work suggests it helps the body's own calming chemicals last longer and touches some of the same brain systems that anti-anxiety pills like benzodiazepines work on. Most of this comes from animal and test-tube studies.
What people use it for
Everyday anxiety and stress
Nervous exhaustion and low energy
Focus and clear thinking (claimed)
A calming option that doesn't make you sleepy like anti-anxiety pills (claimed)
The evidence
Some human studies
There are a few small human studies, nearly all from the Russian teams that made it. In one, 62 people with anxiety or nervous exhaustion got either Selank or an anti-anxiety pill (medazepam), and both eased anxiety about the same; a later study of 60 patients found a similar calming effect. These studies were small, not always well controlled, and haven't been repeated by independent teams, and claims about memory, focus and immunity rest mostly on animal studies.
2 drops of 0.15% solution in each nostril (roughly 100–300 µg per dose, depending on drop size)
How often
3 times a day
When
Spread through the day
Cycle
14 days; the Russian leaflet allows a repeat course after a 1–3 week break
Route
Intranasal drops
Why: This follows the Russian (not FDA) package leaflet. Selank breaks down in the blood within minutes, so it's taken several times a day, and the nose is a fairly direct route to the brain.
Common community use
Reported
Dose
250–500 µg
How often
1–3 times a day
When
Morning and early afternoon; it is not meant as a sleep aid
Cycle
2–4 weeks on, then a break
Route
Intranasal spray or subcutaneous injection
Why: This range is widely shared online but untested in trials. It wears off fast, which is why people split it into more than one dose a day.
Start at the low end, and change one thing at a time. If you take medication or have a health condition, check with a doctor first.
We may earn a commission from these links. Counts include one syringe and two swabs per dose.
Stay safe
Side effects
Bitter or odd taste when drops run down your throat
Irritated nose
Tiredness or mild sleepiness in some people
Allergic reaction (rare)
Skip it if
Pregnant or breastfeeding (no safety data)
Under 18
Known allergy to the peptide or its preservative
Severe anxiety, panic or depression that needs real medical care
Interactions
May add to the effect of sedatives, alcohol, benzodiazepines or sleep pills
Unknown effects with antidepressants; talk to a doctor first
Get help right away for swelling of the face or throat, trouble breathing, chest pain, or a spreading, hot, red injection site.
Storage & legal
Storage
Powder: fridge or freezer. Once mixed, or once a nasal bottle is opened: fridge, use within about 2–4 weeks.
Legal status
FDA: Not approved in the US. Selank acetate was on the FDA's list of compounding substances with safety concerns until the nomination was withdrawn; it is not an approved drug and cannot be legally sold for human use in the US.
Sport (WADA): Not named on the WADA list. Because it is approved in Russia it may not count as a 'non-approved substance' (S0), but this is unclear. Athletes should ask their anti-doping agency before using it.
No. It's a peptide, not a pill like Xanax or Valium. Early research suggests it touches some of the same calming systems, but it hasn't been compared with those drugs in large, independent trials.
Is it habit-forming?
Russian studies didn't report withdrawal or dependence, but they were small and short. Long-term use hasn't been studied.
Why is it taken through the nose?
That's how the Russian medicine is made. Your stomach destroys most peptides, and the nose lets some of it reach the blood and brain quickly.
Sources
Zozulia AA, et al. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48. PubMed 18454096
Medvedev VE, et al. A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(7):17-22. PubMed 25176261
Vyunova TV, et al. Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity. Protein Pept Lett. 2018;25(10):914-923. PubMed 30255741
Doyno CR, et al. Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank. J Clin Pharmacol. 2021;61 Suppl 2:S114-S128. PubMed 34396551
Kost NV, et al. Semax and selank inhibit the enkephalin-degrading enzymes from human serum. Bioorg Khim. 2001;27(3):180-3. PubMed 11443939
US FDA. Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks. Source