Also called 5-amino-1-methylquinolinium, 5A1MQ, NNMT inhibitor
A small molecule that cut fat in obese mice. It hasn't been tested in people.
5-Amino-1MQ is a small molecule, not a peptide, so it works more like a regular pill. University researchers in Texas made it as a lab tool to block an enzyme called NNMT. It gets grouped with peptides because the same people use it, and it's usually taken as a capsule.
NNMT is an enzyme that works overtime in the fat cells of people and animals with obesity, and it uses up raw material cells need to make energy. Blocking it slowed fat storage in lab dishes. In obese mice, it led to less fat and lower weight even though they didn't eat less.
Mostly animal studies
So far it's only been tested in mice and lab dishes. In a key 2018 study, obese mice lost weight and fat and had lower cholesterol without eating less, and later mouse studies found similar results, plus better muscle function in old mice. No human trial has been published, so nobody knows the right dose, how well a pill is absorbed in people, or what long-term use does.
Why: These amounts come from what people commonly use, not from human studies. Taking breaks is a habit borrowed from other supplements; no data shows it's needed or helpful.
Start at the low end, and change one thing at a time. If you take medication or have a health condition, check with a doctor first.
Set up for a 5 mg vial. Change any number to match yours. New to this? Read how to mix a vial and mg vs mL vs units first.
Pick your dose and how long you'll run it. We'll count what you need.
Get help right away for swelling of the face or throat, trouble breathing, chest pain, or a spreading, hot, red injection site.
Capsules or powder: keep cool, dry and out of light. Use the fridge for longer storage.
FDA: Not approved. It is a research chemical, not a legal dietary supplement ingredient.
Sport (WADA): Not named on the WADA list, but non-approved substances are prohibited at all times under S0.
No. It's a small molecule, much smaller than a peptide. That's why it can be taken by mouth.
No published human trials as of October 2026. Everything we know comes from mice and lab dishes.
That's what happened in obese mice. Whether people respond the same way, and at what dose, is unknown.
Last checked 2026-10